My prototype is mis aligning when rendering or leaving massive gaps

My prototype is either showing massive gaps or miss aligning when it is published and showing in a browser.

Help - the whole reason I use axure is to show complexity instead of just making a click-through prototype.

@rmb101 Do you have a sample file that we can look at?

I worked it out - the font displaying in the browser is a smaller font type than the default font displayed in the browser thats what is causing the gaps.
Thanks any way though.