Hmm, by any chance are you on Windows 10, and if so did you recently install the 1803 update? We’ve been receiving reports from users with the above setup where they’ve found that using Axure RP on an external monitor with displays set to something other than 100% seems to cause changes from dropdown menus (such as for color selection) to not stick. We’re investigating this on our end, but if this setup sounds similar to yours then as a workaround for now you can try either moving Axure RP to your main display, setting the display to 100%, or switching your external monitor to be the primary display. Hopefully that helps!